Their ideal 10-0 record during qualifiers feels like a distant memory after narrowly beating Saudi Arabia 2-1 a little over a week ago.
El Tricolor went on another thrilling fast break and pandemonium broke out when crowd favourite Hirving Lozano received Javier Hernandez's pass, skipped past Mesut Ozil, and blasted into Manuel Neuer's net.
And if they finish runners-up to the Mexicans, Germany could be on course to face Brazil in a daunting second-round matchup. "It's great to start on the right foot when you are playing the world champions".
"We shouldn't underestimate them, even if it was a clear win at the Confederations Cup previous year".
And after a run of 25 starts for Germany in all major competitions - the only player now on such a run - he will continue that remarkable record in the starting XI, despite concerns that he would be benched.More news: Rent is rising, wages are not
"It's the most hard feat and history has demonstrated that no one in 60 years has done it", Loew said on Saturday.
Germany nearly hit back four minutes later when Toni Kroos tried his luck from a 22-yard free-kick, but his effort was tipped onto the post by the Mexican keeper.
Such was the scale of his overhaul of the squad that the five-time world champions have only six players with World Cup experience in their ranks, as was the case four years ago.
Germany breezed through qualifying scoring 43 goals and conceding just four and, astonishingly, average nearly four goals a game in their opening World Cup matches since last losing their first tournament game in 1982 against Algeria. Kimmich nearly netted with an over-head kick from 12 yards before Julian Draxler saw a deflected effort go wide of the far post.
The German machines were unable to cope with the quick passing and pace of Mexico's attacks. The German midfield was also very slow in dealing with the fast-paced one touch counter-attacking play of the Mexicans.