But to truly appreciate their dominance, consider this stat: Since the 2003 Wimbledon Championships, 62 Grand Slams have been played, and 51 were won by Federer (20), Nadal (17), or Djokovic (14).
It was after watching Pete Sampras win Wimbledon - while sitting in his parents' pizza parlour as a six-year-old - that Djokovic decided tennis was the sport for him.
Djokovic beat Del Potro, who has had his own injury issues, 6-3 7-6 (7-4) 6-3, and in turn goes level with his hero Pete Sampras or winning 14 career Slam titles.
After taking just two points off Del Potro's first three service games, Djokovic, in his eighth final in NY and 23rd at the majors, pounced to break for 5-3.
He had three more chances in the eighth, all saved by Djokovic in a marathon 20-minute game which left Hollywood superstar Meryl Streep clasping her head in astonishment. One game alone in the second set lasted 20 minutes. After the third round, he did not lose a single set as he was able to outlast a fan favorite in Del Potro.
Since playing on the grass at Queen's Club in June, Djokovic has only lost two matches, while he extended his imposing winning record over Del Potro to 15-4. "I'm very sad for being a loser today but Novak deserved to take the trophy".
This was Djokovic's third championship in NY, along with those in 2011 and 2015.
The crux of the match came midway through the second set.
For world number three Del Potro, it was a heartbreaking experience coming in just his second Slam final, nine years after he was crowned US Open champion.More news: Tesla in turmoil: Stock plunges after executive shakeup
The second set tie-break proved to be the turning point as the Serbian took it and from that point on, his victory on Arthur Ashe Stadium looked inevitable.
This time past year Djokovic was injured and uncertain about his future direction.
That's 85 percent. Quite a contrast to the current state of the women's game, where eight players won the past eight majors. The 29-year said that he is lucky to be competing in the same era as Nadal, Federer and Djokovic.
Naomi Osaka jumped 12 places to a career-high No. 7 in the WTA standings thanks to her first Grand Slam title.
"He knows that he's one of my friends on tour and he knows he's one player I want to watch win on tour".
Despite defeat, world number three Del Potro remained proud after an achievement he never thought would have been possible during his injury hell.
After his latest performance, it's a safe bet Sampras is admiring Djokovic as well - along with many others.
After missing last year's tournament with an injured right elbow that eventually required surgery, Djokovic rubber-stamped his return the top of his game with another major title to add to his fourth Wimbledon crown in July.