Following the breakup, Queen Elizabeth came to Ghana in 1961 - a visit signalling that the two countries were ready to fix severed ties.
Britain's Prince Charles, Prince of Wales (R) is welcomed by Gambia's President Adama Barrow (L), upon his arrival at the airport in Banjul, for an official visit.
The Prince of Wales, who took over the 53-member Commonwealth of Nations in April, last visited Ghana more than 40 years ago.
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"I also call on the United Kingdom with whom we have close historical ties to continue to support us through enhancing trade, investment and economic cooperation", he said.
They were met by government officials with the Speaker of Parliament, Prof Mike Ocquaye spearheading the delegation. The Prince and The Duchess will then attend a traditional durbar or procession at the palace with the Asantehene and local chiefs.
At the reception Prince Charles was presented with a with a birthday cake.
The Prince, who landed in Gambia on Thursday, congratulated the country for turning its back on "autocratic" rule at home and returning to the Commonwealth.
A statement issued by the British High Commission in Accra and copied to the Ghana News Agency said the visit would celebrate the shared values and culture between the two nations.