"The president of the United States has refused to halt arms sales to Saudi Arabia in part because he is more interested in appeasing U.S. defense contractors than holding the Saudis accountable for the murder of a Washington Post journalist or for the thousands of Yemeni civilians killed by those weapons", Warren said in a speech at American University. "Their listing also renders them inadmissible to Canada pursuant to the Immigration and Refugee Protection Act".
They come after allies France, Germany and the United States imposed similar sanctions on these individuals.
The two leaders, who are attending the G20 Summit in Buenos Aires, also discussed Saudi Arabia's readiness to supply India with all its needs of oil and petroleum products and Saudi oil giant Aramco's investments in the fields of oil refining and oil storage in India, SPA said.
The sanctions target Saudi Arabian nationals who are, in the opinion of the government of Canada, responsible for, or complicit in, Khashoggi's killing, Foreign Minister Chrystia Freeland said in the statement.
"We have no smoking gun the crown prince was involved - not the intelligence community or anyone else - there is no smoking gun", Mattis said, adding the USA would still hold those responsible for Khashoggi's death accountable.
"The murder of Jamal Khashoggi is abhorrent and represents an unconscionable attack on the freedom of expression of all individuals", Ms Freeland said.
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In spite of today's sanctions, Canada is still wavering on whether it would cancel arms sales to Saudi Arabia. "World leaders would do well to think twice before posing for pictures next to someone who may come under investigation for war crimes and torture".
Khashoggi, who lived in the U.S. and wrote for the Washington Post, was killed in the Saudi embassy in Turkey.
"There is no direct reporting connecting the crown prince to the order to murder Jamal Khashoggi", Pompeo said.
Seventeen Saudi nationals have been rendered inadmissible to Canada.
It was unclear whether the French president was calling for an global investigation beyond existing Turkish and Saudi probes. This led some lawmakers to call for the U.S.to take a tougher stand against Saudi Arabia.
She said however that the 17 Saudis targeted by Canada are clearly responsible for Mr. Khashoggi's death.