Vertonghen is also not due to be available again for Tottenham until next month as he continues his recovery from a thigh injury while Wanyama is still working his way back from a long-term knee problem.
Asked whether Spurs intend to activate the clause, Pochettino told a news conference: "Yes, for sure, it's obvious".
The north Londoners have provided a full team news and injury update ahead of the game with the latest on the fitness of Dele Alli, Mousa Dembele, Serge Aurier, Victor Wanyama, Eric Dier and Jan Vertonghen.
He was reportedly on Manchester United's radar for much of the summer, but no deal happened and he has enjoyed a second coming at Spurs this season.More news: 'I do' have confidence Treasury Secretary Mnuchin
"I told Daniel (Levy) when he asked me, but you know he is so anxious about such things".
"Our confidence in him is so high and he only needs time to show his quality and match time to try to compete for a place in the starting XI", said Pochettino. But this morning he said to me: 'Gaffer I'm going to be ready.' I said: 'Relax, you need to train this morning and then we'll see tomorrow and assess you'.
The Spurs boss does not want to lose the former Ajax and Atlético Madrid player, with his extension keeping him at the London club until 2020.
According to the Evening Standard, Alderweireld has a £25m release clause that will last up until the final two weeks of the summer transfer window. We translate a lot of emotion to the people.
"But I think it's not going to be easy to add players in January".