Warren said she believes the country is facing "dangerous moment", according to CNN.
Ms Warren announced her campaign in her home state of MA at a mill site where largely immigrant factory workers went on strike about 100 years ago, a fitting forum for the longtime consumer advocate to advance her platform.
"Our fight is for big, structural change", Warren said."That is why I stand here today, to declare that I am a candidate for president of the United States of America".
Her visit at the event, hosted by the National Conference of American Indians, comes after she apologized last week to the Cherokee Nation for releasing a DNA test in October in an attempt to prove she had Native ancestry. Then, the Washington Post learned that Warren hand-wrote "American Indian" as her "race", on a State Bar of Texas registration card from 1986.
On Saturday, Trump's re-election campaign manager was quick to respond to her candidacy and called her "a fraud". Pretending to be an Indian for most of her life in order to gain advantage and power is as bad as the other Democrats applying blackface.
"I'm not sure, at this point, that he could win", Nadell said.More news: Trump attacks Democrats over border security negotiations
But he also cautioned that "it's still very, very early" to speculate on "how it harms her, or doesn't harm her".
"Come on, how many investigations are there now, into him?"
The 69-year-old senator has made the protection of middle-class rights the central pillar of her political message.
But Warren showed nothing but pride in Lawrence's pro-worker history. "I never used it to advance my career". "I am in this fight all the way". Her remarks came amid continued scrutiny of the MA senator's past claims to Native ancestry.
Voters in Cedar Rapids did not ask Warren about the controversy during a question-and-answer session, focusing instead on her stances on issues including tariffs and student loan debt.
Warren tried in her speech to appeal to a broad ethnic coalition, saying, "We must not allow those with power to weaponize hatred and bigotry to divide us".
The senator highlighted several areas where she said Congress must take action, including addressing the rising number of missing and murdered indigenous women and girls; rising suicide rates among Native Americans; as well as resources for housing, health care and addiction treatment.