The Facebook website crashed on several people at KPRC when attempting to access their message inbox on a desktop computer.
As of around 4.30 p.m. ET (1.30 p.m. PT), Facebook seemed to be working for some users, though others remained unable to post.
A Facebook spokesman confirmed the partial outage, but did not provide an update.
Certain users around the world were facing trouble in accessing widely used Instagram, Whatsapp, and Facebook apps earlier on Wednesday, in one of the longest outages faced by the company in the recent past. Facebook issued a message stating that the company is aware of the outage and is working on a fix.
Downdetector.com, a site that monitors site outages, said the Facebook problem affected parts of the US, including the East and West Coast; parts of Europe and elsewhere.
The issue also affected Facebook Workplace, the companies service for businesses to communicate internally.More news: Indian-origin dentist Preethi Reddy murdered in Australia, body found in suitcase
It later added: "We're focused on working to resolve the issue as soon as possible, but can confirm that the issue is not related to a DDoS attack". WhatsApp, Facebook's other messaging app, had similar problems.
Facebook users, including brand marketers, expressed their outrage on Twitter with the #facebookdown hashtag.
"I figured this could happen eventually but it's extremely crippling to be part of this monopoly".
Many people are venting about the problems on Facebook competitor Twitter.
Meanwhile, the social media outage became the butt of jokes on Twitter.
Some users reflected on how the outage had exposed their reliance on the social media networks, while some joked that the lack of access to Facebook would deprive them of validation.