With their rivals involved in the FA Cup quarter-final action tomorrow, Liverpool and Chelsea have the opportunity to seize the initiative in their quest for Premier League and top-four success, respectively.
Juventus will take on young hopefuls Ajax, Tottenham and Man City square off in a mouthwatering all-Premier League meeting and Man United face a Barcelona side containing Luis Suarez and Philippe Coutinho.
"In accordance with paragraph 21.01 (b) of the UEFA Champions League regulations, the UEFA administration will determine which matches will be played on Tuesday, which matches on Wednesday".
"A great occasion, the sort of games that Manchester United are used to and it will be a great night".
But Mills told The Debate the tournament will have no bearing on the quality of the club's season, and explained why City fans would still prefer to retain the Premier League title over a Champions League win - even if their players feel differently.More news: Families of the Ethiopia plane crash victims to wait longer for bodies
Tottenham will host Man City in the first leg on April 9, which could be played at Wembley Stadium or at the north London club's soon-to-be-completed new arena.
Although Barcelona were drawn to play the first match of the tie at home, the match will take place at Old Trafford because of Manchester City's draw.
He admits that playing at home in the second leg could be an advantage, but he was quick to stress the way Manchester United defied the odds against Paris Saint-Germain the previous round. Other teams to qualify were FC Porto, and Tottenham Hotspurs, who defeated Borussia Dortmund in both legs.
Last year's finalists Liverpool recorded an impressive 3-1 aggregate victory over Bayern Munich in the last 16 while Manchester City thrashed Bundesliga strugglers Schalke 10-2 on aggregate to seal their spot in the last eight.
First leg: 9/10 April. "Ajax, they eliminate Real Madrid, Porto (the same) with Roma, everyone is a candidate".
The objective for all is the same: reach the Champions League final in Madrid on 1st June at Estadio Wanda Metropolitano.