The ex-England striker has netted 34 times against the "big six" sides - including five against City - and Rodgers expects him to give the hosts problems.
An equaliser would have seen control of the Premier League title race swing out of City's hands and into Liverpool's.
The Citizens would become the first team in English football history to win all three competitions in the same campaign if they succeed. But the one that came, you have to score that.
"For us it's about super compact pressing at the right moment and when you have the ball, playing quickly at pressure because you'll be pressed in different phases".
Leicester City came into the game with Europa league finish still a possibility, while the Cityzens also needed a victory to move closer to retaining the title they won last season.More news: Homa comes full circle and wins Wells Fargo Championship
It was an abominable effort by Iheanacho, but lack of game-time this season might be a reason for his lack of technicality last night. He got himself in the position ...
"It was tight, we were very, very good in our defensive organisations".
"We are one point in front [before the Newcastle game] against Liverpool and I saw the way they played at Camp Nou and thought, "wow, we are at that level". In my career as a manager, I played against incredible sides and there are two that were "wow".
"But I look at the squad, the potential in the squad, a lot of young players that I believe can develop and can improve".
He went on to have success in Scotland with Glasgow Celtic before his recent return to the Premier League to take the reins at Leicester.
"It's a great challenge against guys that are geniuses like Pep and the other great coaches".